An article by Stanford: "In a new animal study, researchers identified the principal culprit in skin GVHD: an immune cell in the skin known as a Langerhans cell. These cells normally function as flag posts for the immune system, signaling infection-fighting T-cells to come to a particular site to fight off a virus or bacteria. But in transplants, they do patients a great disservice, alerting T-cells to attack the patient's own tissues, researchers found."
Article on Langerhans Cells in BMT patients.
Also, back in 2004 they've found that exposing a patient to ultraviolet light before transplant helps eliminate skin GVHD. Too bad we did not know this.
Saturday, January 13, 2007
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